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hese 5 visible clues reveal insulin resistance long before blood tests

Ouadie RhabbouronMay 9, 2026

One of the very first things I look for is a skin condition known as acanthosis nigricans. Even if you’ve never heard the term, chances are you’ve seen it before. This appears as dark, almost velvety patches of skin that crop up in areas where your skin folds or experiences friction, like the back of your neck, under your armpits, groin, elbow creases, or even on your knuckles.

You might notice these spots look a bit dirty or feel unusually thick. Here’s why: insulin acts as a growth hormone. When it sends a constant “grow, grow, grow” message to your skin cells—especially where sweat and friction are common—the skin in those spots starts to pile up and darken.

2. Skin Tags Popping Up, Especially in Clusters

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